K70.0 K76.0
Conditions
Interventions
Group 1: The project aims to:
quantify 78 serum metabolites from 126 patients with Metabolic-Associated Steatotic Liver Disease and statistically compare them with the quantification of these metabol
Sponsors
Medizinischen Hochschule Brandenburg (MHB) Theodor Fontane
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Healthy subjects, who are working at University Hospital Ruppin-Brandenburg and University Hospital Brandenburg an der Havel. All subjects must be of legal age. Patients of legal age with non-alcoholic and alcoholic liver diseases (liver cirrhosis). 3. Healthy subjects must written declaration of consent (for healthy subjects and patients) must be available.
Exclusion criteria
Exclusion criteria: 1. Healthy subjects and patients who do not meet the inclusion criteria or who their Withdraw consent to participate in the study. 2. Healthy subjects and patients with pregnancies, orthopedic diseases or injuries, traumatic conditions after amputation of extremities, neurologic paresis and central dizziness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is: to address the question whether the quantification of metabolites is useful to discriminate between 126 healthy subjects and patients with specific livere diseases (28 patients with Metabolic-Associated Steatotic Liver Disease (MASLD) or 98 patients with MASLD or increased alcohol intake (MetALD) and Alcohol-Associated Liver Disease (ALD). Additionally, we investigate whether the quantification of metabolites is useful to discriminate between 28 patients with Metabolic-Associated Steatotic Liver Disease (MASLD) and 98 patients with MASLD or increased alcohol intake (MetALD) and Alcohol-Associated Liver Disease (ALD). | — |
Secondary
| Measure | Time frame |
|---|---|
| To comparatively examine, whether in 98 patients with MetALD and ALD the quantification of metabolites is able to discriminate according to currently applied criterias in clinical diagnostics. These criterias are: 1. Child-Pugh Score, 2. Meld Score, 3. HE Score, 4. Ascites, 5. INR Score, 6. BTR Score. | — |
Countries
Germany
Contacts
Public ContactWerner Dammermann
Medizinischen Hochschule Brandenburg (MHB) Theodor Fontane
Outcome results
None listed