Relapsing remitting multiple sclerosis G35.10
Conditions
Interventions
Group 1: In total we will assess 30 patients with a diagnosed relapsing remitting multiple sclerosis. Initially we are going to perform a neuropsychological assessment consisting of the Symbol Digit M
Sponsors
Universitätsmedizin Greifslwald
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: - Reconnaissance capability - Diagnosed relapsing remitting multiple sclerosis
Exclusion criteria
Exclusion criteria: - acute or chronic illnesses (e.g. dermatologic diseases, cardiovascular diseases) - presence of a neurologic disease (RRMS excluded) or psychiatric disease - Medication (exclusion: immunmodulatory medication in RRMS) - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| taVNS (pulse width: 250µs, stimulation frequency: 25Hz, 30sec on/30sec off, Motion threshold: off, Ramp-up: off, Buzzer: off), vs a control condition improves processing speed ability (operationalized with the SDMT-accuracy before and after stimulation) | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) taVNS vs a control condition also improves processing speed ability in healthy individuals (2) magnitude of improvement is more pronounced in MS patients as compared to healthy controls (3) the magnitude of effect is modulated by additional disease variables (disease severity, fatigue, depression) (4) taVNS also has an effect on further non-motor symptoms in MS patients (such as fatigue or depression) | — |
Countries
Germany
Contacts
Public ContactThorsten Herr
Universitätsmedizin Greifswald
Outcome results
None listed