Do We Learn Better After Failures? The Impact of Virtual Reality-Based Sensorimotor Mismatch on the Effectiveness of Motor Learning Processes

Do We Learn Better After Failures? The Impact of Virtual Reality-Based Sensorimotor Mismatch on the Effectiveness of Motor Learning Processes - VRMotorLearn

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034901

Enrollment

Registered

2024-08-22

Start date

2021-04-14

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health problem: persistent motor deficits after, for example, stroke despite current rehabilitation strategies

Interventions

Group 1: Mismatch: intervention group with VR-based, artificially implemented sensorimotor mismatch training (1 session of 10 minutes) Group 2: Error-based: control group with VR-based motor training

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: right-handed, capable of providing informed consent

Exclusion criteria

Exclusion criteria: Contraindications for MRI, pre-existing functional impairment of the upper extremity, severe visual impairment, known neurological or psychiatric disorders

Design outcomes

Primary

Measure	Time frame
Primary study objective: The main research question is how motor learning ability is influenced by preceding artificially induced, virtual reality-based sensorimotor mismatch in comparison to two other learning paradigms. Outcome measure: Behavioral motor learning success in a repeated target task using a computer mouse with the right and left hand, measured immediately after the VR training for 12 minutes per hand.	—

Measure

Time frame

Primary study objective: The main research question is how motor learning ability is influenced by preceding artificially induced, virtual reality-based sensorimotor mismatch in comparison to two other learning paradigms. Outcome measure: Behavioral motor learning success in a repeated target task using a computer mouse with the right and left hand, measured immediately after the VR training for 12 minutes per hand.

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Secondary

Measure	Time frame
Secondary study objectives: - Description of the cortical and subcortical processes induced by the three learning paradigms through analysis of activity and connectivity changes in functional MRI - Description of the relationship between learning success and connectivity changes - Evaluation of the impact of age and pre-existing cerebral microvascular damage on the effect of the mismatch - Comparison of side effects (simulator sickness) and user experience in the three groups including age and sex dependence Outcome measures: - Cortical and subcortical activity and connectivity changes in functional MRI (difference between two resting-state measurements before and after the intervention) - Correlation of behavioral learning success with connectivity changes - Correlation of learning success with age - Correlation of learning success with microvascular changes measured as white matter lesions in MRI - Simulator Sickness Questionnaire (SSQ), assessment using the established questionnaire following the VR training (Factors N, O, D, TS, and individual items in group comparison as well as in relation to age and gender dependence) - User experience (User Experience Questionnaire), assessment using a self-developed questionnaire following the VR training in group comparison including analysis of age and sex dependence	—

Measure

Time frame

Secondary study objectives: - Description of the cortical and subcortical processes induced by the three learning paradigms through analysis of activity and connectivity changes in functional MRI - Description of the relationship between learning success and connectivity changes - Evaluation of the impact of age and pre-existing cerebral microvascular damage on the effect of the mismatch - Comparison of side effects (simulator sickness) and user experience in the three groups including age and sex dependence Outcome measures: - Cortical and subcortical activity and connectivity changes in functional MRI (difference between two resting-state measurements before and after the intervention) - Correlation of behavioral learning success with connectivity changes - Correlation of learning success with age - Correlation of learning success with microvascular changes measured as white matter lesions in MRI - Simulator Sickness Questionnaire (SSQ), assessment using the established questionnaire following the VR training (Factors N, O, D, TS, and individual items in group comparison as well as in relation to age and gender dependence) - User experience (User Experience Questionnaire), assessment using a self-developed questionnaire following the VR training in group comparison including analysis of age and sex dependence

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Countries

Germany

Contacts

Public ContactElisabeth Jochmann

Universitätsklinikum Jena

vrmotorlearn@med.uni-jena.de+4936419323539

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026