F32
Conditions
Interventions
Group 1: Transcranial direct current stimulation with 2mA on the first day of the stimulation sessions (T1) and sham stimulation on the second day (T2) of the stimulation sessions.
Group 2: Sham stimu
Sponsors
Universitätsklinik zu Köln
Eligibility
Sex/Gender
All
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Capacity to consent and agreement from both parents and participants Depressive episode according to ICD-10 criteria Sufficient compliance for participation in the study. In addition to the participants' consent, an anamnesis will be conducted with the participant before the study begins to ensure they can participate for the duration of the study. Sufficient German language skills as determined anamnestically Right-handedness assessed via the Edinburgh Handedness Inventory No antidepressant medication or stable antidepressant medication in the last 6 weeks For sexually active female participants, the use of effective contraception is required. This includes the use of hormonal or barrier contraception.
Exclusion criteria
Exclusion criteria: IQ < 85. The IQ will be assessed through our intelligence testing. IQ diagnostics do not need to be repeated for the study if there is an IQ assessment available that is less than 3 years old. Known comorbid autism spectrum disorder or personality disorder History of epilepsy History of substance abuse as determined by a clinical interview/anamnesis with parents and the participant. Additionally, standardized assessment through our diagnostic interview (e.g., K-DIPS). Current or past ICD-10 diagnoses of F10 – F19 will lead to exclusion from the study. Implanted pacemaker or cochlear implant Chronic use of other medications with psychotropic effects (anticonvulsants, steroids, neuroleptics, benzodiazepines) Anamnestically confirmed pregnancy based on a clinical interview/anamnesis with parents and female participants. Female participants must actively deny the possibility of pregnancy to participate in the study. Additionally, the type of contraception method will be inquired. Autism spectrum disorder, personality disorder, ADHD, eating disorder, obsessive-compulsive disorder, severe anxiety disorders (social phobia, agoraphobia, generalized anxiety disorder), or post-traumatic stress disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effort Maintenance and Invigoration | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG-Reward Positivity, Eye Blink Rate, Heart-Rate Variability during and after stimulation vs. sham Effort maintenancen/Invigoration after stimulation vs. sham Electric Fieldmodelling | — |
Countries
Germany
Contacts
Public ContactJasper Vöckel
Kinder- und Jugendpsychiatrie der Universität zu Köln
Outcome results
None listed