Metabolic profile in boys, adolescents and men with Klinefelter syndrome (47,XXY) and variants - cross-sectional cohort study (comparison to population-based data)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034760

Enrollment

Registered

2024-07-29

Start date

2024-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Klinefelter syndrome (47,XXY and variants) Q98.1

Interventions

Group 1: 10 KS individuals between 0-20 years, recruitment during regular consultation appointments, single study appointment. Parameters: - Testosterone replacement therapy? - Parental height - Fasti

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: - Confirmed diagnosis of Klinefelter syndrome - Signed consent (for underage participants consent by the legal guardian)

Exclusion criteria

Exclusion criteria: - Revocation of the patient's consent/lack of consent - Lack of language skills

Design outcomes

Primary

Measure	Time frame
Prevalence of metabolic syndrome by analysing fasting whole blood sample, physical examination + urine test (one study appointment required)	—

Secondary

Measure	Time frame
- Body composition by body impedance measurement using BIA scales - Insulin resistance (blood sample analysis) - Inflammation parameters (blood sample analysis)	—

Countries

Germany

Contacts

Public ContactCorinna Grasemann

Klinik für Kinder- und Jugendmedizin, St. Josef-Hospital Bochum

corinna.grasemann@rub.de+49 (0)234/509-2601

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026