Non-invasive ultrasound-based quantification of perfusion parameters, fibrosis, inflammation and steatosis in paediatric patients after liver transplantation

Non-invasive ultrasound-based quantification of perfusion parameters, fibrosis, inflammation and steatosis in paediatric patients after liver transplantation - US-LTX-PAED

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034751

Enrollment

120

Registered

2024-07-23

Start date

2024-08-20

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z94.4

Interventions

Group 1: Biopsy of the transplant liver and histopathological evaluation of the liver parenchyma (routine) Group 2: Sonography of the transplant liver using new sonographic techniques and image-based

Eligibility

Sex/Gender

All

Age

No minimum to 17 Years

Inclusion criteria

Inclusion criteria: - Status after liver transplantation - Clinically indicated liver biopsy - Referral for ultrasound examination of the liver - Written informed consent from patient (depending on developmental stage) and legal guardian

Exclusion criteria

Exclusion criteria: - Non-compliance by the patient - No written consent from patient / legal guardian

Design outcomes

Primary

Measure	Time frame
Correlation of sonographic parameters with results of histopathological examination of transplant liver biopsies	—

Secondary

Measure	Time frame
To evaluate novel sonographic methods for characterisation of liver and spleen tissue with quantification of perfusion parameters, fibrotic changes, steatosis and signs of inflammation/rejection. To establish sonography as an alternative/supplement to established invasive techniques for classification of liver parenchymal changes.	—

Countries

Germany

Contacts

Public ContactMichael Esser

Universitätsklinikum Tübingen, Radiologie, Abteilung für Diagnostische und Interventionelle Radiologie

michael.esser@med.uni-tuebingen.de+49(0)7071-29-68429

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026