C00-C14
Conditions
Interventions
Group 1: Patients receive pre-treatment (removal of caries, filling therapy, periodontal pre-treatment, planning of extractions, impression for the distance/fluoridation splint) after inclusion in the
Sponsors
Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Tumor in the oral cavity, oropharynx, hypopharynx or larynx (corresponding to ICD codes C00 - C14), Primary or adjuvant radio- or radio-chemotherapy with curative therapy objective, German language skills, Informed Consent
Exclusion criteria
Exclusion criteria: Palliative tumor therapy; Previous radio therapy in the head and neck area; Pregnancy/breastfeeding period; Allergies to materials used; Small residual dentition (<10); Carious lesions not treated in the dental pre-treatment phase (ICDAS 3, 4, 5, 6); Deep, inflamed, periodontal pockets; Hyposalivation before the start of the study (unstimulated salivary flow rate < 0.1 ml/min or stimulated salivary flow rate < 0.7 ml/min; check during the baseline examination before the biopsy with subsequent exclusion if necessary); Serious blood clotting disorder; Known wound healing disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caries status (ICDAS), unstimulated/stimulated salivary flow rate & residual salivary flow rate (modified Schirmer test), oral mucositis score, cellular radiosensitivity, oral health-related quality of life questionnaire (OHIP-14) | — |
Secondary
| Measure | Time frame |
|---|---|
| Plaque index, periodontal probing depths, bleeding on probing, pH value of stimulated saliva, buffer capacity of stimulated saliva, questionnaire on xerostomia | — |
Countries
Germany
Contacts
Public ContactBenedikt Luka
Medizinische Hochschule Hannover, Klinik für Zahnerhaltung, Parodontologie und Präventivzahnmedizin
Outcome results
None listed