Investigation of the human gut microbiota pre-, during and post long-term stay in sub-Saharan Africa

Investigation of the human gut microbiota pre-, during and post long-term stay in sub-Saharan Africa - RESISTAR

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034691

Enrollment

Registered

2024-08-05

Start date

2024-08-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Changes in gut microbiota after dietary changes due to an overseas stay

Interventions

Group 1: Supplementation with 60g of a resistant starch type 3-containing starch powder (Novelose 330, Ingredion). The measurement takes place before and after the stay in Uganda among healthy partici

Eligibility

Sex/Gender

All

Age

18 Years to 28 Years

Inclusion criteria

Inclusion criteria: • Men / Women, aged 18-28 years (as specified by the weltwärts program) • Residence in Germany • Participation in the weltwärts program with a planned 12-month stay in Uganda

Exclusion criteria

Exclusion criteria: • Not residing in Germany within the last 5 years • Pregnancy • Chronic gastrointestinal diseases (chronic inflammatory bowel diseases, colon cancer, diverticulitis) • Use of antibiotics in the last 4 weeks and/or regularly during the stay abroad (exception: medications for malaria prophylaxis) • Regular use of probiotics (discontinuation at least 2 weeks before examination T0) • Acute gastrointestinal illness (diarrhea) • Family history of chronic intestinal diseases

Design outcomes

Primary

Measure	Time frame
• Levels of short-chain fatty acids in stool, particularly butyrate • Composition and diversity (i.e., alpha- and beta-diversity) of gut microbiota in stool	—

Secondary

Measure	Time frame
• Stool weight • Stool consistency • Stool transit time • Bile acids in stool • Functional microbial genes in stool • Presence of specific bacteria and bacteriophages in stool • Frequency of food consumption • Anthropometric data (weight, height, waist and hip circumference, age, sex, gastrointestinal medical history, vaccinations) • Resting energy expenditure • Body composition • H2/CH4 breath gas analysis • Additional microbiota composition (saliva, skin) • Micronutrients in blood • Trimethylamine-N-oxide (TMAO) in blood	—

Measure

Time frame

• Stool weight • Stool consistency • Stool transit time • Bile acids in stool • Functional microbial genes in stool • Presence of specific bacteria and bacteriophages in stool • Frequency of food consumption • Anthropometric data (weight, height, waist and hip circumference, age, sex, gastrointestinal medical history, vaccinations) • Resting energy expenditure • Body composition • H2/CH4 breath gas analysis • Additional microbiota composition (saliva, skin) • Micronutrients in blood • Trimethylamine-N-oxide (TMAO) in blood

—

Countries

Germany

Contacts

Public ContactSören Ocvirk

Technische Universität München

soeren.ocvirk@tum.de+49 (0) 8161-71 2026

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026