Beta-cell function and autoantibody patterns in long-standing type 1 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034682

Enrollment

100

Registered

2024-07-16

Start date

2014-06-17

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E10

Interventions

Group 1: Patients with type 1 diabetes receive in the morning a mixed meal tolerance test with measurement of plasma C-peptide at 0 and 90 minutes.

Eligibility

Sex/Gender

All

Age

30 Years to No maximum

Inclusion criteria

Inclusion criteria: Diabetes mellitus Type 1 Diabetes duration longer than 30 years Insulin therapy since diabetes manifestation Blood glucose on the day of the examination 4-11 mmol/l

Exclusion criteria

Exclusion criteria: eGFR < 60 ml/min Pregnancy

Design outcomes

Primary

Measure	Time frame
Increase of plasma C-Peptid during Mixed Meal Tolerance Test	—

Secondary

Measure	Time frame
Positivity for diabetes autoantibodies (GADA, IA-2A, ZnT8A)	—

Countries

Germany

Contacts

Public ContactWolfgang Kerner

Klinikum Karlsburg, Herz- und Diabteszentrum Mecklenburg-Vorpommern

kerner@drguth.de+49 38355 70 1397

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026