Influence of nociception-level controlled epidural anesthesia on perioperative analgesic requirements

Influence of nociception-level controlled epidural anesthesia on perioperative analgesic requirements - EPINOL

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034633

Enrollment

Registered

2024-07-19

Start date

2024-10-30

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

No specific disease

Interventions

Group 1: Group 1 (NOL): n = 40 NOL oriented anesthesia Group 2: Group 2 (NOL): n = 40 non-NOL oriented anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ? Written declaration of consent ? Elective surgical or diagnostic procedure under combined general and epidural anesthesia in abdominal and visceral surgery and urology

Exclusion criteria

Exclusion criteria: - Pre-existing arrhythmias such as atrial fibrillation, grade II and III AV block - Pacemaker therapy - Drug abuse (narcotics) or opiate habit - Pregnancy and breastfeeding - Chronic pain syndrome and pain therapy - Severe PAD (grade IV) - Simultaneous participation in another study that influences the outcome parameters

Design outcomes

Primary

Measure	Time frame
? Effect of NOL on perioperative analgesic requirements ? Effect of NOL on perioperative catecholamine requirements	—

Secondary

Measure	Time frame
? Recording of the most important patient data such as age, height, gender, ASA classification, previous illnesses, previous medication ? Recording of various factors influencing NOL (perioperative stimuli such as intubation, positioning, skin incision, etc.) ? Recording of hemodynamic events ? Recording of the intraoperative volume status ? Recording cerebral oxygenation and autoregulation ? Postoperative recording of patient satisfaction and pain ? Preoperative recording of a cognitive deficit ? Postoperative recording of delirium ? Postoperative recording of awareness ? Evaluation of morbidity ? Length of stay in intensive care unit and length of hospital stay ? Mortality	—

Measure

Time frame

? Recording of the most important patient data such as age, height, gender, ASA classification, previous illnesses, previous medication ? Recording of various factors influencing NOL (perioperative stimuli such as intubation, positioning, skin incision, etc.) ? Recording of hemodynamic events ? Recording of the intraoperative volume status ? Recording cerebral oxygenation and autoregulation ? Postoperative recording of patient satisfaction and pain ? Preoperative recording of a cognitive deficit ? Postoperative recording of delirium ? Postoperative recording of awareness ? Evaluation of morbidity ? Length of stay in intensive care unit and length of hospital stay ? Mortality

—

Countries

Germany

Contacts

Public ContactAlexander Ziebart

Klinik für Anästhesiologie

alexander.ziebart@unimedizin-mainz.de06131172437

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026