C00-C14 C30 C31 C32
Conditions
Interventions
Group 1: Only cancer patients with a confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) who have been treated at the Heidelberg University Hospital (experimental validation with tumo
Sponsors
Universität Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Confirmed diagnosis of head and neck squamous cell carcinoma - Availability of tumour samples from the NCT tissue bank (experimental validation with tumour tissue) - Planned surgical tumour resection as part of routine treatment at the University Hospital Heidelberg (experimental validation in the preclinical model)
Exclusion criteria
Exclusion criteria: - Nonage - Patients who lack full legal capacity and consent - Diagnosis of squamous cell carcinoma not confirmed by histopathology - Small size or quality of available tumour tissue - Withdrawal of consent for use of samples or data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Experimental validation of potential regulators and targets of UCHL1 in tumour tissue - Experimental validation of bioinformatic models of UCHL1-dependent modulation of the TME in tumour tissue - Proof of concept (PoC) of selected inhibitors and regulation of potential structures in tumour tissue and derived preclinical models | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association of demographic, histopathological and clinical parameters with UCHL1 expression and function - Association of demographic, histopathological and clinical parameters with efficacy of selected inhibitors and expression of relevant target structures | — |
Countries
Germany
Contacts
Public ContactJochen Heß
Universitätsklinikum Heidelberg
Outcome results
None listed