Infectious Diseases, unspecified
Conditions
Interventions
Group 1: MEDICS is a prospective, longitudinal cohort study designed to investigate clinical, molecular and immunological aspects of infectious diseases. The main objective of the study is to improve
Sponsors
Charité - Universitätsmedizin Berlin, Klinik m.S. Infektiologie und Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: At least one of the following criteria: - Clinical sign(s) of infection, e.g. fever (calor), redness (rubor), impaired organ function (functio laesa) - Paraclinical signs of infection: CRP = 15mg/l and/or leukocytes outside the age-appropriate norm - Planned antiinfective therapy - Microbiological/virological infection diagnostics
Exclusion criteria
Exclusion criteria: - Presence of medical reasons that speak against the withdrawal of blood volume - Imprisonment - Person with unclear or invalid insurance status
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of high-dimensional flow cytometric analysis of circulating immune cells for the differentiation of viral, bacterial, parasitic and/or mycotic infectious agents (incl. co-infections) in comparison to established methods (diagnostic gold standard and established clinical scores plus extended diagnostic procedures). | — |
Secondary
| Measure | Time frame |
|---|---|
| -Precision of the determination of disease severity in patients with viral, bacterial, parasitic and/or mycotic infectious agents (incl. co-infections) using high-dimensional flow cytometric analysis of circulating immune cells compared to established methods (diagnostic gold standard and established clinical scores plus extended diagnostic procedures). -Sensitivity and specificity of high-dimensional flow cytometric analysis of circulating immune cells for the differentiation of viral, bacterial, parasitic and/or mycotic infectious agents (incl. co-infections) in comparison to controls without infectious disease in comparison to established methods (diagnostic gold standard and established clinical scores plus extended diagnostic procedures). | — |
Countries
Germany
Outcome results
None listed