DSM-5: 300.4 Persistent depressive disorders ICD-11: 6B41 Complex post-traumatic stress disorder F33 F60.31 F43.1 F45
Conditions
Interventions
Group 1: Patients with borderline personality disorder, episodic depression, persistent depressive disorder, (complex) post-traumatic stress disorder, or somatic stress disorder are recruited on an ou
Sponsors
LMU Klinikum, Klinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: We will include participants with sufficient German language skills to perform all questionnaires, interviews and introductions of the behavioral paradigm. Patients have to meet diagnostic criteria of one of the following main diagnoses according to the DSM-5: Diagnosis of a BPD (301.83), PDD (300.4, 296.2x, 296.3x, 296.3x), cPTSD (309.9), ED (296.xx) or SSD (300.82). Healthy controls have to not fulfill a psychiatric disorder assessed within a screening.
Exclusion criteria
Exclusion criteria: Clinical participants will be excluded if fulfilling DSM-5 criteria of an active substance-dependency (abstinence shorter than 6 months), a psychotic disorder or a bipolar I or II disorder or acute suicidality (as main or comorbid diagnosis). Participants will be screened and diagnosed by a trained clinician based on the DSM-5 criteria (SCID-5-CV and SCID-5-PD interview). All Individuals will be excluded if having a current or past somatic or neurological disorders with effects on the brain or if currently pregnant. Non-clinical participants will be excluded when having a history of a psychiatric disorder or a psychotherapeutic/psychopharmacological intervention within the last 10 years (reviewed by telephone screening and psychometric assessments). Participants with a regular (daily) current intake of benzodiazepines will be excluded due to confounding aspects for the experimental cyberball paradigm and the psychometric questionnaires.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of adverse childhood experiences clusters (ACE clusters) and cumulative ACE risk across rejection sensitivity (RS) outcome. Behavioral, affective, pneurophysiological and neuroendocrinological responses to social response to social exclusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in disorder-specific symptoms (depression, BPD, kPTBS, SSD), traumatization, loneliness, aggression, social network, resilience, attachment style, mentalization, DSM-5 personality pathology, quality of life, interpersonal problems, emotion regulation, and alterations in oxytocin system depending on ACE and RS. Naturalistic longitudinal study of clinical and biological predictors, mediators and moderators of 10-week disorder-specific psychotherapy (CBASP, DBT). | — |
Countries
Germany
Contacts
Public ContactAndrea Jobst-Heel
LMU Klinikum, Klinik für Psychiatrie und Psychotherapie
Outcome results
None listed