J96.9 J96.0
Conditions
Interventions
Group 1: Patients randomized to the intervention group receive high-flow oxygen therapy starting at 40 L/min. The inspiratory oxygen fraction is automatically set on the ventilator based on the derive
Sponsors
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerzmedizin, Universitätsmedizin Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with hypoxemic respiratory failure admitted to IMC ward 37-4 or ICU 32-3 - Need for HFOT with = 40 L/min with a FiO2 = 0.30 - HFOT foreseeable on admission for at least 24 hours
Exclusion criteria
Exclusion criteria: - Age = 18 years - Pregnancy - Expected or present dyshemoglobinemia - Poor signal quality of SpO2 measurement at finger and ear (quality index 1 mg/h) - Severe respiratory acidosis with pH < 7.25 - Difference between SpO2 and SaO2 of more than 5%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of time spent with SpO2 below the prescribed range during the HFOT observation period. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Proportion of time during which the patient's SpO2 is higher than the defined SpO2 target during high-flow oxygen therapy. - Proportion of time in which the patient's SpO2 is outside the defined SpO2 target during high-flow oxygen therapy. - Workload for caregivers, assessed by o Number of manual changes in FiO2 o Number of alarms caused by hypoxia or hyperoxia - Total amount of oxygen consumed by the patient - Severity of respiratory distress and patient comfort - If postoperative: rate of anastomotic insufficiencies - HFOT failure with need for invasive or non-invasive ventilation - Variability of the SpO2/FiO2 ratio over time - Retrospective segmentation of CT imaging | — |
Countries
Germany
Contacts
Public ContactJörg Krebs
Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerzmedizin, Universitätsmedizin Mannheim
Outcome results
None listed