Influence of preoperative focused echocardiography on anesthesiologic management in the setting of urgent operative fracture care in adults - a multicentric observational trial

Influence of preoperative focused echocardiography on anesthesiologic management in the setting of urgent operative fracture care in adults - a multicentric observational trial - TRANSONIC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034557

Enrollment

500

Registered

2024-06-27

Start date

2024-10-13

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T02.6

Interventions

Group 1: Performance of a perioperative hemodynamically focused transthoracic echocardiography (PFE) according to the recommendations of the German Society of Anesthesiology and Intensive Care Medicin

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: Guideline-compliant surgery for the treatment of a fracture of a large tubular bone (Femur, Humerus, Radius, Ulna, Tibia, Fibula) under general anaesthesia of any surgical urgency classification; patients capable of giving informed written consent; Age >= 65 years

Exclusion criteria

Exclusion criteria: Participation in another prospective interventional study involving the cardiovascular system; placement by court or official order; previous participation in TRANSONIC; patients who do not speak German

Design outcomes

Primary

Measure	Time frame
Percentage of change in the perioperative anesthesiologic management due to findings in a preoperative PFE of all included study participants	—

Secondary

Measure	Time frame
Incidence of pathological findings; duration of surgery; duration of anaesthesia; intraoperative blood loss; duration of invasive ventilation; incidence and duration of dialysis; length of hospital stay; intraoperative and ICU requirements for catecholamines/inotropes; blood products and volume; intensive care scores including TISS, SOFA and SAPS; occurrence of organ complications and dysfunctions; routinely recorded vital signs and their indices (blood pressure, heart rate, cardiac index, stroke volume, SVV, SVI, PPV); invasive ventilation settings; lactate; base excess; haemoglobin; creatinine concentration; central venous pressure; diuresis; post-operative further anaesthesiologic management/care and monitoring (recovery room, post-anaesthesia care unit (PACU), intensive care unit); length of stay in intensive care unit; 4-point scale for assessing the image quality of PFE (poor, moderate, good, excellent quality); hospital-, 30-day-, six-month- and 1-year mortality; readmission to the hospital within one year	—

Measure

Time frame

Incidence of pathological findings; duration of surgery; duration of anaesthesia; intraoperative blood loss; duration of invasive ventilation; incidence and duration of dialysis; length of hospital stay; intraoperative and ICU requirements for catecholamines/inotropes; blood products and volume; intensive care scores including TISS, SOFA and SAPS; occurrence of organ complications and dysfunctions; routinely recorded vital signs and their indices (blood pressure, heart rate, cardiac index, stroke volume, SVV, SVI, PPV); invasive ventilation settings; lactate; base excess; haemoglobin; creatinine concentration; central venous pressure; diuresis; post-operative further anaesthesiologic management/care and monitoring (recovery room, post-anaesthesia care unit (PACU), intensive care unit); length of stay in intensive care unit; 4-point scale for assessing the image quality of PFE (poor, moderate, good, excellent quality); hospital-, 30-day-, six-month- and 1-year mortality; readmission to the hospital within one year

—

Countries

Germany

Contacts

Public ContactRalf Felix Trauzeddel

Klinik für Anästhesiologie und Intensivmedizin, Charité - Universitätsmedizin Berlin, Charité Campus Benjamin Franklin

ralf-felix.trauzeddel@charite.de+49 30 450 651684

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026