Effect of psychological or physical traumatization on the course and outcome of interdisciplinary orthopedic-psychosomatic rehabilitation of chronic multilocular pain syndromes.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034556

Enrollment

420

Registered

2025-02-11

Start date

2021-04-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F45.41 F45.40 M79.70

Interventions

Group 1: Observation group In the patients included in the study, both psychological test questionnaires and blood samples for the later laboratory determination of various biomarkers are taken at the

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Chronic multilocular pain syndromes: ICD-10 F45.40, F45.41, M79.7

Exclusion criteria

Exclusion criteria: Insufficient knowledge of the German language to independently complete a questionnaire, refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
1) Intensity and duration of chronic pain: DGSS (Pain Questionnaire of the German Pain Society) 2) Reduction of chronic stress experience: (TICS)	—

Secondary

Measure	Time frame
The following psychological assessments are conducted at the beginning and end of interdisciplinary rehabilitation treatment: • PHQ-D (health questionnaire for patients)) • KERF (questionnaire to determine stressful childhood experiences) • TICS (Trier Inventory for the Assessment of Chronic Stress) • PTSS-10 (questionnaire on PTSD symptoms) • DGSS (Pain questionnaire - German Society for the Study of Pain) • BEVA (questionnaire for complaint validation) The biomediators listed below are determined in the laboratory at the beginning and end of the interdisciplinary rehabilitation treatment (serum level determination and cell activity measurements): • Cortisol • hsCRP, IL-6, IL-10: “Inflammasome” • CXCL10: Sickness behavior • Leptin, cholesterol, EPA: lipid metabolism • AEA (anandamide), 2-AG: ECS • Zonulin: microbiome (brain-gut axis) • Homocysteine: mitochondrial metabolism • 25(OH)VitD3: cell nucleus metabolism • BDNF, dopamine: (peripheral) sensitization • miRNA - 183 cluster • miRNA-320 cluster	—

Measure

Time frame

The following psychological assessments are conducted at the beginning and end of interdisciplinary rehabilitation treatment: • PHQ-D (health questionnaire for patients)) • KERF (questionnaire to determine stressful childhood experiences) • TICS (Trier Inventory for the Assessment of Chronic Stress) • PTSS-10 (questionnaire on PTSD symptoms) • DGSS (Pain questionnaire - German Society for the Study of Pain) • BEVA (questionnaire for complaint validation) The biomediators listed below are determined in the laboratory at the beginning and end of the interdisciplinary rehabilitation treatment (serum level determination and cell activity measurements): • Cortisol • hsCRP, IL-6, IL-10: “Inflammasome” • CXCL10: Sickness behavior • Leptin, cholesterol, EPA: lipid metabolism • AEA (anandamide), 2-AG: ECS • Zonulin: microbiome (brain-gut axis) • Homocysteine: mitochondrial metabolism • 25(OH)VitD3: cell nucleus metabolism • BDNF, dopamine: (peripheral) sensitization • miRNA - 183 cluster • miRNA-320 cluster

—

Countries

Germany

Contacts

Public ContactMarkus Prof. Dr. Bassler

Hochschule Nordhausen

markus.bassler@hs-nordhausen.de+49 3631420575

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026