Post-COVID (or post acute sequelae of SARS-CoV-2) U09
Conditions
Interventions
Group 1: Intervention containing elements of strength and endurance training, relaxation and breathing exercises. The intervention group is introduced to the app during the baseline assessment, throug
Sponsors
Sport- und Rehabilitationsmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - persistent symptoms (neurocognitive/physical impairments) after SARS-CoV infection - signed declaration of consent and - signed transfer of ownership agreement
Exclusion criteria
Exclusion criteria: Severe end organ damage / cardiac disease with moderately to severely reduced LV function - Concomitant diseases that represent a contraindication for physical activity (e.g. immobilization, serious myopathies) - Limited ability to cooperate (e.g. serious psychiatric and/or neurological illnesses) - Existing pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints are health-related quality of life, cognitive performance, and physical performance (VO2peak). Health-related quality of life is assessed using the German version of the SF-12 (Health Status Questionnaire, Morfeld et al.). According to the questionnaire manual, the core dimensions "Physical Health" and "Mental Health" are determined. Cognitive performance is measured using the Symbol Digit Modalities Test (SDMT, Smith). VO2peak is examined as part of cardiopulmonary performance diagnostics. The primary endpoints are assessed both at the time of the baseline examination and after the eight-week intervention (final examination). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints of the study are: - concentrations of inflammatory markers (IL-1ß, IL-6, TNF-alpha, CRP) - level of Kynurenine, Kynurenic acid, Quinolinic acid (and respective ratios) - echocardiographic parameters (e.g., LV GLS, RV GLS, RV RWS, E/A, E/E'l, E/E'm, etc) - Parameters of Cardio Pulmonary Exercise Testing - Mental health (Severity of depressive symptoms, anxiety and stress) All secondary endpoint parameters are assessed both at the time of the baseline examination and at the final examination (after 8 weeks). | — |
Countries
Germany
Contacts
Public ContactJohannes Kirsten
Sport- und Rehabilitationsmedizin
Outcome results
None listed