Comparison of different provocation maneuvers in the measurement of the left ventricular outflow tract (LVOT) gradient in patients with hypertrophic (obstructive) cardiomyopathy (H(O)CM)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034473

Enrollment

100

Registered

2024-09-11

Start date

2024-09-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I42.1

Interventions

Group 1: Patients with hypertrophic obstructive cardiomyopathy (HOCM) in whom a Doppler sonographic measurement of the gradient in the left ventricular outflow tract (LVOT) is measured at rest, while

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Diagnosis of HOCM according to the diagnostic criteria specified in the European Society of Cardiology 2023 guideline "Cardiomyopathy"

Exclusion criteria

Exclusion criteria: - severe underlying disease other than cardiomyopathy that is likely to lead to death within one year - Incapable of giving consent - Inability to undergo stress echocardiography (e.g. severe osteoarthritis of the knee joint) - Pregnant women

Design outcomes

Primary

Measure	Time frame
Maximum size of the LVOT gradient provoked by physiological provocation measured by Doppler ultrasonography during a cardiac ultrasound examination while performing the Valsalva maneuver, while using a handgrip, after squats and during bicycle stress echocardiography.	—

Countries

Germany

Contacts

Public ContactMaximilian N. Möbius-Winkler

Universitätsklinikum Leipzig AöR, Klinik und Poliklinik für Kardiologie

kardiologie@uniklinik-leipzig.de+493419712650

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026