Radiation-induced DNA repair mechanisms and chromosomal changes
Conditions
Interventions
Group 1: Blood samples are to be taken from medical staff and patients during before and after vascular surgery procedures with expected radiation exposure. Procedure-associated radiation dose values
Sponsors
Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Written consent to participate in the study, capacity to consent Additionally for patients: Medically justifiable indication provided by the attending physician for radiological diagnostics/intervention for elective endovascular procedures Additionally for staff: Proper application of the usual radiation protection measures
Exclusion criteria
Exclusion criteria: Under 18 years of age, discontinuation/refusal of radiological examination, lack of written consent from the patient, pregnancy, emergency endovascular interventions, autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Specific acute DNA repair markers, more precisely the activity determination of the y-H2A.X histone protein, are to be examined after radiation exposure. The investigated markers of the blood samples before and after radiation exposure will be compared. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is assumed that both the activity of ?-H2A.X and chronic chromosomal changes (e.g. dicentric chromosomes or chromosome translocations) correlate with the radiation dose. | — |
Countries
Germany
Contacts
Public ContactPhilipp Erhart
Universitätsklinikum Heidelberg
Outcome results
None listed