E11
Conditions
Interventions
Group 1: RSOM measurements, proteomic, metabolomic and genetic analysis at time 1.
RSOM measurements, proteomic and metabolomic analysis at time 2 (12-15 months after time 1).
Group A: 200 patients w
Sponsors
Lehrstuhl für Biologische Bildgebung, Technische Universität München
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: Group A: Patients with diagnosed diabetes mellitus type II without vascular complications. Group B: Patients with diagnosed diabetes mellitus type II with at least one microvascular complication (e.g. neuropathy, nephropathy and retinopathy) without macrovascular complications. Group C: Patients with diagnosed diabetes mellitus type II with microvascular complications and at least one macrovascular complication (e.g. coronary heart disease, carotid atherosclerosis, peripheral arterial occlusive disease). Group D: 200 healthy participants
Exclusion criteria
Exclusion criteria: -Refusal to give consent to participate in the study -Pregnancy or breastfeeding -Highly pigmented skin (leads to a strong attenuation of the RSOM signal due to the presence of melanin in the skin) -Documented or suspected light allergy, light intolerance, contact dermatitis and particularly sensitive skin or dermatological diseases (e.g. psoriasis) -History of smoking (only in healthy subjects) -Use of a pacemaker, insulin pump or other implanted electronic devices -Open or infected wounds at the measurement sites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (A) How are the RSOM measurements correlated with the stage (presence of vascular complications) of diabetes and the cardiovascular risk profile? (B) How are RSOM measurements correlated with the genetic, metabolic and proteomic profile of patients with diabetes? RSOM measurement data Protein biomarkers and metabolites Genotyping, QTLs | — |
Secondary
| Measure | Time frame |
|---|---|
| (A) How are the RSOM measurements correlated with the sonographic findings? (B) How are the RSOM measurements correlated with the light spectrometry findings? | — |
Countries
Germany
Contacts
Public ContactIvy Curren
Lehrstuhl für Biologische Bildgebung, Technische Universität München
Outcome results
None listed