Prophylactic Pylorus Dilatation prior to Esophagectomy Randomized trial

Prophylactic Pylorus Dilatation prior to Esophagectomy Randomized trial - PROPPER Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034360

Enrollment

118

Registered

2024-05-29

Start date

2024-08-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C15

Interventions

Group 1: endoscopic preoperative pylorus dilatation Group 2: No endoscopic preoperative pylorus dilatation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Histological proven squamous cell carcinoma or adenocarcinoma of the intrathoracic esophagus or gastroesophageal junction, planned as minimally invasive esophagectomy (RAMIE/MIE) with intrathoracic anastomosis. Surgical resectability, cT1-4a, cNx, cM0 Age = 18 and = 80 ECOG performance status 0 – 2 Written consent

Exclusion criteria

Exclusion criteria: Carcinoma of the cervical esophagus Functional inoperability Preoperation concerning the stomach or the pylorus Esophageal stenosis at time of potential study inclusion

Design outcomes

Primary

Measure	Time frame
rate of pyloric dysfunction	—

Secondary

Measure	Time frame
Major and minor postoperative complication rates, adverse events during gastroscopy, mortality, length of ICU and hospital stay and quality of life	—

Countries

Germany, Italy

Contacts

Public ContactPeter Grimminger

Universitätsmedizin Mainz, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie

peter.grimminger@unimedizin-mainz.de+4961317291

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026