C74
Conditions
Interventions
Group 1: Children and adolescents with a neuroblastic tumor who receive an MRI examination for clinical reasons and after weighing up the benefits and risks.
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: - Clinical indication for MRI in preoperative MRI imaging before local therapy for high-risk/+IDRF neuroblastoma or postoperative MRI imaging after local therapy of a high-risk/+IDRF neuroblastoma to evaluate a possible tumor residual - Presence of all necessary laboratory parameters (creatinine/GFR without evidence of high-grade renal insufficiency; GFR >30 ml/min) - Written consent to the study from the patient and/or legal guardian
Exclusion criteria
Exclusion criteria: -Presence of implants that are not MR-compatible or any type of metal in or on the body (e.g. pacemakers, artificial heart valves, metal prostheses, implanted magnetic metal parts, etc. that are not MR-compatible) - Non-compliance of the patient for an MRI examination and any study-related extension of the examination time. - No written consent to the study from the patient and/or legal guardian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Multiparametric analysis of neuroblastic tumors for tissue differentiation - Establishment of a standardized preoperative and early postoperative MRI for the analysis and evaluation of tumor residuals with influence on further therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| - Establishment of novel diffusion-based parameters - T1 and T2 mapping of neuroblastic tumors for vitality assessment, response, prognosis and tumor differentiation | — |
Countries
Germany
Contacts
Public ContactSebastian Gassenmaier
Universitätsklinikum Tübingen
Outcome results
None listed