Effects of Extracorporeal Procedures on Inflammation, Endothelial function, Coagulation, and Outcome in patients undergoing Lung transplantation (EPIECOL-trial)

Effects of Extracorporeal Procedures on Inflammation, Endothelial function, Coagulation, and Outcome in patients undergoing Lung transplantation (EPIECOL-trial) - EPIECOL

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034312

Enrollment

Registered

2024-05-22

Start date

2024-08-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Transplantation Z94.2

Interventions

Group 1: Lung transplantation without va-ECMO Group 2: Lung transplantation with va-ECMO Group 3: Lung transplantation with va-ECMO + Cytosorb

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Double lung transplantation - Declaration of consent available - Patient of legal age - Preoperative no extracorporeal procedure

Exclusion criteria

Exclusion criteria: - Patient refusal to participate in the study - Peripherally cannulated va-ECMO or postoperative use of vv-ECMO

Design outcomes

Primary

Measure	Time frame
Investigation of the effects of extracorporeal circulation (va-ECMO and va-ECMO + adsorber) on chemokine and cytokine expression profiles in comparison to a cohort without extracorporeal circulation in the first 3 days after transplantation	—

Secondary

Measure	Time frame
1. investigation of the effects of extracorporeal circulation (va-ECMO and va-ECMO + adsorber) on endothelial function compared to a cohort without extracorporeal circulation in the first 3 days after transplantation 2. investigation of the effects of extracorporeal circulation (va-ECMO and va-ECMO + Cytosorb®) on coagulation activation compared to a cohort without extracorporeal circulation in the first 3 days after transplantation 3. investigation of the immune response using leukocyte subpopulations depending on the selected procedures in the first 3 days after transplantation 4. evaluation of 28-day mortality 5. recording the number of patients with primary graft failure in the three groups 6. recording the number of patients with acute postoperative renal failure in the three groups 7. documentation of the number of blood and plasma products administered intraoperatively 8. evaluation of the need for vasopressors in the three groups during the operation 9. investigation of perioperative troponin changes in the three groups	—

Measure

Time frame

1. investigation of the effects of extracorporeal circulation (va-ECMO and va-ECMO + adsorber) on endothelial function compared to a cohort without extracorporeal circulation in the first 3 days after transplantation 2. investigation of the effects of extracorporeal circulation (va-ECMO and va-ECMO + Cytosorb®) on coagulation activation compared to a cohort without extracorporeal circulation in the first 3 days after transplantation 3. investigation of the immune response using leukocyte subpopulations depending on the selected procedures in the first 3 days after transplantation 4. evaluation of 28-day mortality 5. recording the number of patients with primary graft failure in the three groups 6. recording the number of patients with acute postoperative renal failure in the three groups 7. documentation of the number of blood and plasma products administered intraoperatively 8. evaluation of the need for vasopressors in the three groups during the operation 9. investigation of perioperative troponin changes in the three groups

—

Countries

Germany

Contacts

Public ContactChristina Scharf-Janßen

LMU Klinikum

christina.scharf-janssen@med.uni-muenchen.de004989440044152

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026