Infection history of children within the first year of life with regard to family history, pregnancy & birth, living conditions, nutrition, etc.
Conditions
Interventions
Group 1: Single arm observational study:
Healthy term children (>37+0 gestational weeks) are followed over a period of one year and biosamples are obtained as well as data is collected. Time points st
Sponsors
Lehrstuhl für Translationale Pädiatrie - Kinderklinik am Universitätsklinikum Würzburg
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a) Mature newborn (gestational age 37+0-41+6 gestational weeks) b) Place of residence of the family in the city or district of Würzburg c) Birth in the Department of Gynecology and Obstetrics of the University Hospital Würzburg
Exclusion criteria
Exclusion criteria: a) Congenital immunological or metabolic systemic diseases b) Severe congenital malformation c) Amniotic Infection Syndrome d) Neonatal sepsis in the first 72 hours of life e) In the next 12 months, change of residence outside the city or district of Würzburg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective: To investigate the postnatal transcriptional reprogramming of human respiratory and innate systemic immunity as a function of the composition and function of the gut microbiome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective a: Analysis of the relationship between the composition and function of the respiratory microbiome and the postnatal transcriptional reprogramming of human respiratory immunity. Secondary objective b: To determine the effect of perinatally released S100A8/A9 on the development of the respiratory and dermal microbiome. | — |
Countries
Germany
Contacts
Public ContactDorothee;Carina Viemann;Hartmann
Lehrstuhl für Translationale Pädiatrie - Kinderklinik am Universitätsklinikum Würzburg;Lehrstuhl für Translationale Pädiatrie - Kinderklinik am Universitätsklinikum Würzburg
Outcome results
None listed