Concentrations of reactive oxygen species in cerebrospinal fluid in patients with thoracic and thoraco-abdominal aorta surgery

Concentrations of reactive oxygen species in cerebrospinal fluid in patients with thoracic and thoraco-abdominal aorta surgery - LIOX

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00034231

Enrollment

Registered

2024-10-17

Start date

2025-03-26

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I71

Interventions

Group 1: Patients with thoracic or thoraco-abdominal aortic aneurysms The observation period is from 03/2025 - 08/2026

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients with planned operations on the thoracic and thoraco-abdominal aorta with preoperative placement of a cerebrospinal fluid drainage

Exclusion criteria

Exclusion criteria: -Younger 18 years -Research project rejected

Design outcomes

Primary

Measure	Time frame
Concentration of reactive oxygen species [ROS] (including hydrogen peroxide (H2O2)) in cerebrospinal fluid (CSF) Five collection points from the CSF drainage 1. The evening before the operation 2. Before skin incision 3. Shortly before aortic clamping (approx. 1-5 min) or before full deployment of the stent graft (approx. 1-5 min) 4. After removal of the aortic clamp (approx. 1-5 min) or after complete expansion and deployment of the stent graft (approx. 1-5 min) 5. On the 1st postoperative day in the intensive care unit (prior to removal of the CSF drainage) parameter • Clinical data ° all routine data from the medical record ° Somatosensory evoked potentials (SEP's) and motor evoked potentials (MEP's) • From CSF drainage ° ROS ° H2O2 ° Dopamine ° Serotonin ° Glutamate ° Melatonin and orexin ° lactate	—

Measure

Time frame

Concentration of reactive oxygen species [ROS] (including hydrogen peroxide (H2O2)) in cerebrospinal fluid (CSF) Five collection points from the CSF drainage 1. The evening before the operation 2. Before skin incision 3. Shortly before aortic clamping (approx. 1-5 min) or before full deployment of the stent graft (approx. 1-5 min) 4. After removal of the aortic clamp (approx. 1-5 min) or after complete expansion and deployment of the stent graft (approx. 1-5 min) 5. On the 1st postoperative day in the intensive care unit (prior to removal of the CSF drainage) parameter • Clinical data ° all routine data from the medical record ° Somatosensory evoked potentials (SEP's) and motor evoked potentials (MEP's) • From CSF drainage ° ROS ° H2O2 ° Dopamine ° Serotonin ° Glutamate ° Melatonin and orexin ° lactate

—

Secondary

Measure	Time frame
- Suitability of electron spin resonance and Amplex Red hydrogen peroxide/peroxidase assay for the determination of reactive oxygen species (including hydrogen peroxide (H2O2)) from cerebrospinal fluid - Correlation of the neurological outcome with the ROS measurements	—

Countries

Germany

Contacts

Public ContactFriedhelm Beyersdorf

Universitätsklinikum Freiburg

friedhelm.beyersdorf@uniklinik-freiburg.de+4976127061960

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026