C49 C49 C25 C15 C16 C18 C19 C22 C50 C43 C25
Conditions
Interventions
Group 1: Historical Tumor Board Decisions: This arm contains the actual historical decisions made by multidisciplinary tumor boards for oncological patients, based on the existing anonymized clinical
Sponsors
Universitätsmedizin mannheim
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with confirmed diagnoses of cancers. - Cases with comprehensive documentation of tumor board decisions and clinical data.
Exclusion criteria
Exclusion criteria: - Cases lacking comprehensive documentation of tumor board decisions or missing significant clinical data. - Patients whose cases were discussed in emergency settings outside regular tumor board meetings.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| "Degree of concordance between the historical tumor board decisions and recommendations generated by various LLM approaches (Base LLM, RAG-enhanced LLM, and Fine-tuned LLM), measured using a 5-point Likert scale (1 = no concordance at all, 5 = complete concordance). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison of the concordance rate between the three LLM approaches (Base LLM vs. RAG-enhanced LLM vs. Fine-tuned LLM). - Evaluation of the clinical applicability of LLM-generated recommendations by expert specialists. - Analysis of concordance rates by tumor entity (colorectal carcinoma, primary liver tumors, soft tissue sarcomas). - Assessment of the accuracy of LLM recommendations in relation to current medical guidelines. - Identification of specific clinical scenarios or patient groups in which LLMs generate particularly precise or imprecise recommendations. | — |
Countries
Germany
Contacts
Public ContactCui Yang
Universitätsmedizin Mannheim
Outcome results
None listed