All patients are eligible for liver transplantation, including whole organ transplantation, split liver transplantation and retransplantation.
Conditions
Interventions
Group 1: It is a monocentric, non-interventional, clinical obeservation study in the context of liver transplantation.
Sponsors
Universitätsklinum Essen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All consenting adult patients undergoing liver transplantation at the University Hospital Essen will be included. Although this includes women of childbearing potential who are not using contraception, a medical implication is excluded as this is a non-interventional study.
Exclusion criteria
Exclusion criteria: Lack of capacity to consent in patients who are minors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Are the results of viscoelastic coagulation analysis using the newer ROTEM sigma rotational thrombelastometer in the context of liver transplantation comparable to the previous clinical standard ROTEM delta device. To test the correlation between the clotting time (CT) in the extrinsically activated EXTEM assay with Quick/INR, the CT in the intrinsically activated INTEM assay with aPTT, and the clot strength at 5 minutes (amplitude at 5 min, A5) and total clot firmness (maximum clot firmness, MCF) in the extrinsically activated FIBTEM assay under in vitro platelet function inhibition with Clauss fibrinogen concentration compared to ROTEM sigma and ROTEM delta. Can FXIII deficiency be unmasked by viscoelastic testing. | — |
Secondary
| Measure | Time frame |
|---|---|
| The aim is to compare whether the handling of the ROTEM sigma offers advantages for the user. For this purpose, the pre-analysis time and the time to the first measured values are compared for both methods. Clinical relevance of FXIII deficiency in liver transplant patients both early (transfusion requirement) and mid-term (wound healing disorders) after liver transplantation. | — |
Countries
Germany
Contacts
Public ContactBjörn Breuing
Universitätsklinikum Essen
Outcome results
None listed