A prolonged aPTT often results in postoperatively inadequate anticoagulation, which could lead to an increased rate of thromboembolic events.
Conditions
Interventions
Group 1: Patients undergoing major cardiac surgery using the heart-lung machine
Sponsors
LMU Klinikum München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients undergoing major cardiac surgery with intraoperative use of the heart-lung machine - Consent of the patient or caregiver - Age > 18 years
Exclusion criteria
Exclusion criteria: - Refusal to participate in the study by the patient or caregiver - Age < 18 years - Congenital or acquired coagulation disorders (both pro- and anticoagulatory) - Blood-thinning medication in a time window of less than 12 hours before the operation, with the exception of antiplatelet agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Factor XII activity preoperatively versus after the end of the extracorporeal perfusion time | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlation of factor XII activity with aPTT - Correlation of factor XII activity with CT INTEM - Correlation of factor VIII activity with CT INTEM or aPTT - Correlation of factor V activity with CT INTEM or aPTT - Correlation of factor activities with thromboembolic events or bleeding events - Correlation of factor activities with transfusion volumes | — |
Countries
Germany
Contacts
Public ContactPhilipp Groene
LMU Klinikum München
Outcome results
None listed