Multimodal single-cell profiling for hip osteoarthritis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034164

Enrollment

Registered

2024-05-08

Start date

2023-03-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Group 1: Individual chondrocyte cells derived from hip osteoarthritis affected primary cartilage tissue with low levels of cartilage degradation according to the OARSI score. Group 2: Individual chon

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Only inclusion of white Europeans to initially determine genetic changes within a specific ethnic group.

Exclusion criteria

Exclusion criteria: Infections, necrosis of the femoral head, disorders of bone metabolism, rheumatoid arthritis or other inflammatory arthritis, post-traumatic osteoarthritis, treatment with bisphosphonates, lupus, gout, pregnancy

Design outcomes

Primary

Measure	Time frame
Identifying gene expression and regulatory changes in hip osteoarthritis at the single cell level.	—

Secondary

Measure	Time frame
Create an atlas of single cell expression and chromatin accessibility which can provide new insights into processes that regulate the pathogenesis of hip osteoarthritis.	—

Countries

Germany

Contacts

Public ContactSusanne Mayer

Ludwig-Maximilians-Universität München-Klinikum, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Universitätszentrum München (MUM)

susanne.mayer@med.uni-muenchen.de+49 152 54889941

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026