Investigation of genotype-phenotype correlations in patients with neurofibromatosis type I using three-dimensional shape analysis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034121

Enrollment

150

Registered

2025-05-14

Start date

2025-07-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q85.0

Interventions

Group 1: Patients with diagnosed NF1 requiring orthodontic treatment Group 2: Patients with diagnosed NF1 requiring no for orthodontic treatment Group 3: Siblings without NF1 Group 4: Patients without

Eligibility

Sex/Gender

All

Age

4 Years to 18 Years

Inclusion criteria

Inclusion criteria: - Genetic detection of NF1 - Patient/guardian consent to the study - Participation in no other study

Exclusion criteria

Exclusion criteria: - Patient wishes exclusion - Patient does not attend the check-up appointments

Design outcomes

Primary

Measure	Time frame
Differences in extraoral characteristics between patients with neurofibromatosis type I receiving supportive orthodontic therapy and untreated patients at the end of growth.	—

Secondary

Measure	Time frame
- Differences in oral health status are found - Differences in periodontal health are found - Differences in caries experiences are found - Differences in quality of life index - Differences in skelettal growth	—

Countries

Germany

Contacts

Public ContactTheodosia Bartzela

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Anstalt des öffentlichen Rechts des Freistaates Sachsen

Theodosia.Bartzela@ukdd.de+49 351 4582718

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026