Validity and reliability testing of the Timed-Up and Go Test in patients with haemophilia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034103

Enrollment

Registered

2024-04-19

Start date

2024-04-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

D66 D67

Interventions

Group 1: In this study, the Timed-Up and Go Test (TUG) will be psychometrically evaluated for validity and reliability in patients with haemophilia. The TUG is a simple and widely used clinical test t

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Adult diagnosed with moderate and severe haemophilia A or B. - age = 18 years

Exclusion criteria

Exclusion criteria: - Suffering from other bleeding diseases outside of haemophilia - any invasive joint therapies (e.g., radiosynoviorthesis) or surgeries (e.g., TEP or arthrodesis) up to 6 months before the examination date - acute analgesic drug intake outside of the patient’s regular treatment regime 12 hours before the examination.

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the convergent construct validity: The validity of the TUG is assessed by correlating the results of the TUG (time in seconds) with those of the already validated "Haemophilia Joint Health Score" (a test to assess joint health; score range 0-124), and with an established objective clinical test measuring the same construct, namely the Short Physical Performance Battery (SPPB), which includes the 5-time sit to stand test and the 4-meter walk test; score range 0-12). Additionally, the results are correlated with subjective measures of physical function and mobility, including the Haemophilia Activity List (HAL; score range 0-100), the Haemophilia and Exercise Project-Test-Questionnaire (HEP-Test-Q; score range 0-100), and subjective weekly physical activity time (time in minutes per week).	—

Measure

Time frame

The primary endpoint is the convergent construct validity: The validity of the TUG is assessed by correlating the results of the TUG (time in seconds) with those of the already validated "Haemophilia Joint Health Score" (a test to assess joint health; score range 0-124), and with an established objective clinical test measuring the same construct, namely the Short Physical Performance Battery (SPPB), which includes the 5-time sit to stand test and the 4-meter walk test; score range 0-12). Additionally, the results are correlated with subjective measures of physical function and mobility, including the Haemophilia Activity List (HAL; score range 0-100), the Haemophilia and Exercise Project-Test-Questionnaire (HEP-Test-Q; score range 0-100), and subjective weekly physical activity time (time in minutes per week).

—

Secondary

Measure	Time frame
- Test-Retest Reliability - Inter-Rater Reliability - Discriminant (known groups) construct validity - Standard error of measurement - Minimum detectable change	—

Countries

Germany

Contacts

Public ContactFabian Tomschi

Bergische Universität Wuppertal, Lehrstuhl für Sportmedizin

tomschi@uni-wuppertal.de+49 202 373 208 16

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026