I60.9
Conditions
Interventions
Group 1: The present study is based on a patient cohort from various neurosurgical intensive care units across Germany. Patients are treated in their respective clinics according to current guidelines
Sponsors
Universitätsklinikum Knappschaftskrankenhaus Bochum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - From onset to treatment = 48 hours; - SAB confirmed by head CT, MRI or three-glass sample; - Signed informed consent form.
Exclusion criteria
Exclusion criteria: - Severe neurological deficits before onset (mRS = 2); - Uncontrolled severe hypertension (systolic pressure =180 mmHg or diastolic pressure =110 mmHg after drug treatment); - Severe coagulation abnormalities; - Contraindication for RIPC: The upper extremity has severe soft tissue injuries, fractures or vascular injuries, distal perivascular lesions of the upper extremities, etc; - Participation in other clinical trials within 3 months; - Lack of informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is now the qualitative and quantitative investigation of the influence of intra- and extracranial inflammatory processes on the pathogenesis, the rupture and the spontaneous course of vascular anomalies of the central nervous system based on various laboratory chemical analyses of parameters. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Risk factor analysis with regard to outcome and disease progression (e.g. Operative approach, gender, age, neuroradiological findings, secondary diseases) with development of detailed risk scales - Assessment of quality of life after surgical intervention (SF-36, BDI) - Influence of inflammation (e.g. expression rate of inflammation-associated cytokines (e.g. IL-6, IL-10, TNF-a) at mRNA and protein level) on the angioarchitecture, morphological and haemodynamic properties and the appearance in the imaging of the vascular malformation, as well as the clinical outcome of the patients after an intervention - Influence of genetic and epigenetic factors on outcome | — |
Countries
Germany
Contacts
Public ContactKatharina Rump
Universitätsklinikum Knappschsftskrankenhaus Bochum
Outcome results
None listed