(Suspected) aplastic anaemia
Conditions
Interventions
Group 1: In this registry, clinical data (symptoms, laboratory parameters, etc.) of patients with: aplastic anemia
congenital aplastic syndrome
congenital syndrome associated with cytopenia or unclear cytopenia are documented. In addition, the quality of life is documented (questionnaire) and biomaterial is collected for defined research proj
Sponsors
Uniklinik RWTH Aachen, Klinik für Hämatologie, Onkologie, Hämostaseologie und SZT
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients suspected of having aplastic anaemia, a congenital aplastic syndrome, a congenital syndrome associated with cytopenias or an unclear cytopenia and blood is sent to the registry centre in Aachen for telomere length determination and, if necessary, genetic diagnostics. Consent to the registry, biobanking and transmission of blood for telomere length determination and, if necessary, genetic diagnostics to the registry center in Aachen.
Exclusion criteria
Exclusion criteria: No exclusion criteria are explicitly formulated. In particular, patients with comorbidities and a non-curative intended therapy can be explicitly included in order to generate a picture of the reality of care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Central collection of basic epidemiological data such as age, gender, clinical parameters - The interpretation of the telomere lengths in the overall context of the data and the corresponding diagnosis as well as the time course - The association of clinical parameters with telomere length and with new experimental biomarkers as prognostic or predictive markers | — |
Secondary
| Measure | Time frame |
|---|---|
| - The recording of clinical endpoints: Overall survival, disease-specific mortality - The association of epidemiological baseline data and clinical outcomes with telomere length and other markers - Recording and describing curative and supportive therapy options | — |
Countries
Germany
Contacts
Public ContactTim Henrik Brümmendorf
Uniklinik RWTH Aachen, Klinik für Hämatologie, Onkologie, Hämostaseologie und SZT
Outcome results
None listed