Association of different phenotypes of neutrophil granulocytes and proinflammatory cytokines with the pathogenesis and the progression of periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034061

Enrollment

132

Registered

2024-04-11

Start date

2026-03-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K08.9

Interventions

Group 1: Young patients with periodontitis - Periodontal diagnosis, blood sample, sulcus fluid sample (baseline, after treatment, follow-up) - Periodontal therapy Group 2: Older patients with periodon

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria for one patient - Age: = 18 years - ASA status 1 and 2 - Non-smoker - Consent of the patient

Exclusion criteria

Exclusion criteria: Exclusion criteria for a patient - Children (underage patients) - Poor general condition (ASA status =3) - No consent from the patient - Less than 20 teeth - Stage I, II, IV periodontitis - Pregnancy - Diabetes mellitus - Rheumatoid arthritis - Diseases with immunosuppression - Patients with an increased risk of infective endocarditis - Patients with increased risk of drug-induced osteonecrosis of the jaw

Design outcomes

Primary

Measure	Time frame
Tooth loss enquiry 60 months after the start of the study	—

Secondary

Measure	Time frame
Periodontal status after 6, 12, 24, 36 and 48 months	—

Countries

Germany

Contacts

Public ContactMatthias Folwaczny

Poliklinik für Zahnerhaltung und Parodontologie

matthias.folwaczny@med.uni-muenchen.de+4989440059301

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026