Recurrent urinary tract infections N30
Conditions
Interventions
Group 1: Women with recurrent urinary tract infections (rUTI): longitudinal sampling (urine, vaginal swab, stool) over 6 months with biweekly sampling and whenever an UTI occurs + assessment of UTI
Gr
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: rUTI cohort: - Adult women with recent history of rUTI defined as =3 UTI during the last 12 months or =2 UTI during the last 6 months - Urogenital anatomical abnormalities allowed in small subgroup (n=5) Control group: single UTI - Adult women with symptomatic community-acquired uncomplicated UTI at time of inclusion; symptoms include dysuria, increased urinary frequency and urgency OR Adult women with history of single UTI in last 5 years without recurrences afterwards - Absence of symptoms for alternative urogenital infections including vaginal discharge and vaginal pain at time of UTI presentation
Exclusion criteria
Exclusion criteria: Both groups: Pregnancy Control group: - Known anatomical abnormalities in the lower urinary tract - UTI in previous 6 months - Antibiotic treatment in previous 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the potential of therapeutic interventions targeting intestinal, vaginal or urinary microbiota for the prevention of rUTI | — |
Secondary
| Measure | Time frame |
|---|---|
| - Genomic relatedness of causative uropathogens with intestinal and vaginal bacteria of the same species assessed by WGS - Identification of distinct urinary, vaginal and intestinal microbiota signatures that confer resilience to recurrent disease in women - Investigation of interdependent changes and interactions between urinary and intestinal or vaginal microbiota - Assessment of risk factors for emergence of MDRB as causative pathogens of rUTI | — |
Countries
Germany
Contacts
Public ContactLena M. Biehl
Uniklinik Köln
Outcome results
None listed