Z31
Conditions
Interventions
Group 1: Patients with an indication for ART
During ovarian hyperstimulation, dental examination and sampling of oral plaques for microbiome analysis, as well as blood sampling for metabolome analyses
Sponsors
Univeristitätsklinikum Heidelberg
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: • Capacity to consent - Signed declaration of consent and consent to the data protection regulations - No contraindication for clinical-dental probing to determine the periodontal status (Z.n. endocarditis, immunosuppression, Z.n. radiotherapy in the head and neck area) - No known general diseases that could have an influence on the oral microbiome
Exclusion criteria
Exclusion criteria: -Existing pregnancy - Immunosuppressive therapy - Taking medication that can have an effect on (gingival) inflammation - Presence of a serious general illness including illnesses with a high risk of endocarditis, immunosuppression and existing infectious diseases (e.g. HIV) - Non-compliance with the study-related requirements (oral hygiene in the last 12 hours before sample collection) - vaginal infections - acute infections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The target criteria are differences in the oral and vaginal microbiome and metabolome in women with successful ART (pregnancy) compared to unsuccessful ART. 14 days after follicular puncture, ßHCG is determined from the blood. Pregnancy exists if a positive cardiac action is detected on ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Live births only in direct connection with the ART cycle under investigation | — |
Countries
Germany
Contacts
Public ContactSabine Keß
Universitätsfrauenklink Heidelberg
Outcome results
None listed