Olfactory Training in Patients with migraine with and without Aura

Olfactory Training in Patients with migraine with and without Aura - OT in Migraine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033962

Enrollment

Registered

2025-04-22

Start date

2019-12-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G43.9

Interventions

Group 1: olfactory training (with scents) Duration: 3 months olfactory training with 3 pens, twice daily, approximately 10s each pen Group 2: placebo training Duration: 3 months placebo training with

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: understanding study tasks, using of an headache diary

Exclusion criteria

Exclusion criteria: sinunasal disease, anosmia

Design outcomes

Primary

Measure	Time frame
The mechanical pain perception threshold is the value in mN above which a mechanical stimulus is perceived as painful. The mechanical pain perception threshold is investigated using PinPricks, which are small metal pins that exert standardised force when they hit the surface (skin). The threshold is determined in increasing and decreasing intensity in 5 measurement repetitions. The parameter is analysed at the beginning of the study and after 3 months of olfactory or placebo training.	—

Measure

Time frame

The mechanical pain perception threshold is the value in mN above which a mechanical stimulus is perceived as painful. The mechanical pain perception threshold is investigated using PinPricks, which are small metal pins that exert standardised force when they hit the surface (skin). The threshold is determined in increasing and decreasing intensity in 5 measurement repetitions. The parameter is analysed at the beginning of the study and after 3 months of olfactory or placebo training.

—

Secondary

Measure	Time frame
olfactory threshold: is a point value and is determined by means of a smell test, depending on the dilution level from which a fragrance is smelled, a point value is assigned, the higher the point value, the higher the dilution level and the olfactory ability mechanical pain sensitivity,: measures pain sensitivity to mechanical stimuli and is determined using quantitative sensory testing (QST) electrical pain threshold: measures how much mA a direct current stimulus is perceived as painful (using Digitimer Ltd: Medical and Laboratory Scientific Instruments) All parameters are analysed at the beginning of the study and after 3 months of olfactory or placebo training.	—

Measure

Time frame

olfactory threshold: is a point value and is determined by means of a smell test, depending on the dilution level from which a fragrance is smelled, a point value is assigned, the higher the point value, the higher the dilution level and the olfactory ability mechanical pain sensitivity,: measures pain sensitivity to mechanical stimuli and is determined using quantitative sensory testing (QST) electrical pain threshold: measures how much mA a direct current stimulus is perceived as painful (using Digitimer Ltd: Medical and Laboratory Scientific Instruments) All parameters are analysed at the beginning of the study and after 3 months of olfactory or placebo training.

—

Countries

Germany

Contacts

Public ContactGUDRUN GOSSRAU

TU Dresden, medizinische Fakultät, Universitätsklinikum Drseden, USC

Gudrun.Gossrau@ukdd.de+493514582063

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026