Correlation between postoperative neurocognition and perioperative subclinical cerebral ischemia in cardiac surgery patients (a retrospective analysis)

Correlation between postoperative neurocognition and perioperative subclinical cerebral ischemia in cardiac surgery patients (a retrospective analysis) - CONCISE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033944

Enrollment

332

Registered

2024-03-25

Start date

2024-03-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive decline (no ICD-code available)

Interventions

Group 1: Correlation between postoperative neurocognition and perioperative subclinical cerebral ischemia in cardiac surgical patients (A retrospective analysis)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Elective cardiac surgical procedure (on-pump) - Coronary Artery Bypass Grafting (CABG) - Aortic Valve Replacement (AVR) - Mitral Valve Replacement/Reconstruction (MVR) - Combination (CABG+AVR, CABG+MVR, AVR+MVR, CABG+AVR+MVR) Good knowledge of the German language, as the neuropsychological tests are language-dependent. Patient age > 18 Written consent from patients to participate in the study

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
How frequently do postoperative cognitive deficits (POCD) occur in patients with subclinical cerebral ischemia (SCI)?	—

Secondary

Measure	Time frame
1. Does the volume of SCI correlate with the extent of POCD? 2. Are there specific cortical topographic regions with SCI associated with specific postoperative neuropsychological dysfunctions? 3. Are there specific cortical networks with SCI associated with specific postoperative neuropsychological dysfunctions? 4. Are there specific vascular territories with SCI associated with specific postoperative neuropsychological dysfunctions? 5. Are there preoperative neurocognitive impairments associated with the risk of developing postoperative SCI? 6. Are there preoperative psychopathological disorders (depression, anxiety) associated with the risk of developing postoperative SCI? 7. Does the extent of preoperative cognitive impairments correlate with the volume of SCI? 8. Which perioperative variables (duration of surgery, bypass time, clamp time) are associated with postoperative SCI?	—

Measure

Time frame

1. Does the volume of SCI correlate with the extent of POCD? 2. Are there specific cortical topographic regions with SCI associated with specific postoperative neuropsychological dysfunctions? 3. Are there specific cortical networks with SCI associated with specific postoperative neuropsychological dysfunctions? 4. Are there specific vascular territories with SCI associated with specific postoperative neuropsychological dysfunctions? 5. Are there preoperative neurocognitive impairments associated with the risk of developing postoperative SCI? 6. Are there preoperative psychopathological disorders (depression, anxiety) associated with the risk of developing postoperative SCI? 7. Does the extent of preoperative cognitive impairments correlate with the volume of SCI? 8. Which perioperative variables (duration of surgery, bypass time, clamp time) are associated with postoperative SCI?

—

Countries

Germany

Contacts

Public ContactMarius Butz

Kerckhoff-Klinik, Heart and Brain Research Group

m.butz@kerckhoff-klinik.de+49(0)6032/996 5812

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026