Stimulus-Induced EEG Reactivity in Neuroprognosis after Severe Brain lnjury

Stimulus-Induced EEG Reactivity in Neuroprognosis after Severe Brain lnjury - SIREN

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033926

Enrollment

Registered

2024-03-25

Start date

2023-08-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coma (including UWS and MCS-) after severe brain injury

Interventions

Group 1: Comatose patients with stimulus-induced EEG reactivity: Patients who show reactivity in the EEG to stimuli (optical, acoustic, pain stimuli or medication, such as amantadine, which was admini

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Coma or UWS (Unresponsive Wakefulness Syndrome) No general anaesthesia within = 24 hours, no sedative medication within = 24 hours

Exclusion criteria

Exclusion criteria: Pre-existing impairment of consciousness Hypoxic-ischemic encephalopathy (HIE) Status epilepticus Withdrawal of life support/palliative care Administration of neuromuscular relaxants Administration of psychoactive medication

Design outcomes

Primary

Measure	Time frame
3 months GOS-E & mRS	—

Secondary

Measure	Time frame
12 months GOS-E & mRS in hospital survival EQ-5D-5L questionnare ICU length of stay length of invasive ventilation cumulative Amantadin dose	—

Countries

Germany

Contacts

Public ContactKonstantinos Dimitriadis

LMU Klinikum

konstantin.dimitriadis@med.uni-muenchen.de08944000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026