Pain Processing
Conditions
Interventions
Group 1: Experimental Group:
Subjects receive Naloxone (intravenous injection): Bolus dose of 0.15mg/kg body weight before commencement of the computer task
followed by a perfusion of 0.2mg/kg/h over a duration of 1 hour 15 minutes.
Group 2: Placebo Control Group: Subjects receive an intravenous Saline injection (same dosis and durations as Naloxone condi
Sponsors
Institut für systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: • Healthy, adult participants • German at native speaker level • Right-handedness
Exclusion criteria
Exclusion criteria: • Acute or chronic pain (including sore muscles) • Presence of acute or chronic somatic or psychiatric illnesses (based on self-report) • MR-specific exclusion criteria (e.g. claustrophobia, pacemaker, non-MR-compatible metallic foreign bodies) • Participation in studies with medication, or regular use of medication (except thyroid, allergy medication, occasional use of painkillers, contraceptives) within the last 2 months before start of the examination • Taking painkillers within the last 24 hours before the start of the examination • Fear of needles/blood samples • Pregnancy or breastfeeding • Acute skin disease or injury in the areas to be stimulated • Acute illness or symptoms of the respiratory tract (e.g. exercise-induced asthma) • Past or existing physical opioid dependence • Cardiovascular disease (e.g. angina pectoris) • Disease of the nervous system • Disease of the immune system • Disease of the gastrointestinal tract • Ingestion of cardiotoxic drugs/substances (e.g. cocaine, metamphetamine, cyclic antidepressants, calcium antagonists, beta blockers, digoxin) • Metallic hardware in the body (e.g. IUDs, stents, ferromagnetic bone screws, etc.) • Electromagnetic devices (e.g. pacemakers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is to investigate whether the motivation to engage in an action in order to receive a monetary reward leads to pain reduction mediated by endogenous opioids. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary aim is the examination of neuronal mechanisms of pain modulation by motivation | — |
Countries
Germany
Contacts
Public ContactLeonard Asan
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Outcome results
None listed