Effect of acute metformin ingestion on blood lactate kinetics in type 2 diabetes patients chronically treated with metformin

Effect of acute metformin ingestion on blood lactate kinetics in type 2 diabetes patients chronically treated with metformin - Metformin & Exercise in Diabetes (MEDia)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033840

Enrollment

Registered

2024-06-24

Start date

2024-08-14

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E11

Interventions

Group 1: Type 2 diabetes – metformin (On the experimental day, patients will take metformin for breakfast and a placebo for lunch. They will maintain their usual metformin dosage and frequency but wil

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Type 2 diabetes group: - BMI 25-35 kg/m2 and with a sedentary lifestyle (<150 min/week moderate-intensity exercise); - diagnosed as type 2 diabetes = 1 year; - prescribed immediate-release metformin twice per day = 3 months Non-diabetes group: - BMI 25-35 kg/m2 and with a sedentary lifestyle (<150 min/week moderate-intensity exercise); - no diagnosed of type 2 diabetes.

Exclusion criteria

Exclusion criteria: - insulin treatment within 12 months prior to the start of the study; - chronic prescription of other medications; - fasting glucose concentrations >16 mmol/L; - serious diabetic complications (e.g., nephropathy, retinopathy, and neuropathy); - any contraindications for undertaking exercise testing (e.g. acute infectious diseases or chronic inflammation).

Design outcomes

Primary

Measure	Time frame
Capillary blood lactate concentrations during the two-hour postprandial period, submaximal exercise test, sprint test, and recovery phase	—

Secondary

Measure	Time frame
(1) Capillary blood glucose concentrations during the two-hour postprandial period, submaximal exercise test, sprint test, and recovery phase. (2) Energy expenditure during the postprandial period, submaximal exercise test, sprint test, and recovery phase (estimated by indirect calorimetry). (3) The first and second lactate thresholds in the submaximal exercise test. (4) Peak power (PP), mean power output (MP), and total work performed (TW) in the sprint test. (5) Metabolic biomarkers (i.e., insulin, glucagon, C-peptide, non-esterified fatty acids [NEFAs], and glycerol) during fasting, 2 hours postprandial, and after the submaximal exercise test.	—

Measure

Time frame

(1) Capillary blood glucose concentrations during the two-hour postprandial period, submaximal exercise test, sprint test, and recovery phase. (2) Energy expenditure during the postprandial period, submaximal exercise test, sprint test, and recovery phase (estimated by indirect calorimetry). (3) The first and second lactate thresholds in the submaximal exercise test. (4) Peak power (PP), mean power output (MP), and total work performed (TW) in the sprint test. (5) Metabolic biomarkers (i.e., insulin, glucagon, C-peptide, non-esterified fatty acids [NEFAs], and glycerol) during fasting, 2 hours postprandial, and after the submaximal exercise test.

—

Countries

Germany

Contacts

Public ContactTong Zhao

German Sport University Cologne

tong.zhao@stud.dshs-koeln.de+ 49 17687882820

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026