K74
Conditions
Interventions
Group 1: Cohort A: Data collection from patients with liver cirrhosis on wards without ward pharmacists' support (retrospective)
Group 2: Cohort B: Data collection as part of the introduction of routi
Sponsors
Uniklinikum Bonn
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with liver cirrhosis of any origin and severity - Inpatients of the Hufeland ward of the Medical Clinic I of the University Hospital Bonn - Minimum length of stay of 24 hours, as the inpatient admission criterion is then fulfilled - Cohort B and C: At least one screening by the ward pharmacists responsible for the ward
Exclusion criteria
Exclusion criteria: - Patients under 18 years of age - Pregnancy and breastfeeding patients - Patients who were not hospitalised or were hospitalised for < 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of frequency for drug-related problems in patients with liver cirrhosis vs. without application of the consensus-validated treatment recommendations over the entire case duration | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Comparison of cohort B vs. cohort A (each data collected over the entire case duration): - Comparison of the number and type of drug-related problems in patients with liver cirrhosis - Severity of identified drug-related problems according to NCC MERP - Preventability of the identified drug-related problems (ABPs) - Number and type of (re-)admissions (liver-associated, non-liver-associated, drug-associated) within the observation period - Number of emergency admissions within 30 days (day 0 = discharge day) - Number and type of patient deaths (liver-associated, non-liver-associated, drug-associated) - Correlation of number of ABPs found with: -- Age (geriatric vs. non-geriatric) -- gender -- Severity of liver cirrhosis according to Child-Pugh -- Comorbidity burden CCI = 5 according to Charlston Comorbidity Index (CCI) -- Number of medications taken (< 5, =5, =7, =10) -- Number of emergency admissions 2) Comparison of cohort C vs. cohort B (each data collected over the entire case duration): - Comparison of the number and type of drug-related problems in patients with liver cirrhosis - Severity of identified drug-related problems according to NCC MERP - Preventability of the identified drug-related problems (ABPs) - Number and type of (re-)admissions (liver-associated, non-liver-associated, drug-associated) within the observation period - Number of emergency admissions within 30 days (day 0 = discharge day) - Number and type of patient deaths (liver-associated, non-liver-associated, drug-associated) - Correlation of number of ABPs found with: -- Age (geriatric vs. non-geriatric) -- gender -- Severity of liver cirrhosis according to Child-Pugh -- Comorbidity burden CCI = 5 according to Charlston Comorbidity Index (CCI) -- Number of medications taken (< 5, =5, =7, =10) -- Number of emergency admissions 3) Acceptance rate and rationale for rejection of routine clinical practice recommendations by ward pharmacists and treating physicians | — |
Countries
Germany
Contacts
Public ContactMaria Katharina Karsten Dafonte
Uniklinikum Bonn
Outcome results
None listed