Z94.0
Conditions
Interventions
Group 1: Kidney Transplant Recipients (de-novo/retransplanted)
N=300
In arm 1, we will examine changes in the human virome longitudinally and compare viral composition pre-transplant to 3/6/12/36 mont
Severe infections N=120-180 (40-60%)
Rejections (clinical acute rejection and subclinical rejection of any type including Borderline changes) N=15-120 (5-40%).
Estimated cases within the representative cohort of N=300: occurrence of BK-
occurrence of BK Nepropathy 1-10% (N=3-30)
Group 2: In arm 2, we will explore differences in polyomavirus genotypes regarding the development of BK nephropathy post-transplantation. If available, we f
Sponsors
Nierenzentrum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -de-novo/re-transplanted -present consent
Exclusion criteria
Exclusion criteria: -no biomaterial available
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigate changes in the human virome in sequencing data of biomaterial from kidney transplant patients in longitudinal section and compare the viral composition before transplantation with 3/6/12/36 months after transplantation | — |
Secondary
| Measure | Time frame |
|---|---|
| -Differences between polyomavirus genotypes in relation to the development of BK nephropathy -Association of certain viral genotypes with certain types of cancer at the time of initial diagnosis Malignancy | — |
Countries
Germany
Contacts
Public ContactLouise Benning
Nierenzentrum Heidelberg
Outcome results
None listed