Impact of a concurrent multimodal prehabilitation program on functional status, quality of life and surgical outcome in patients undergoing neoadjuvant treatment for resectable non-small cell lung cancer

Impact of a concurrent multimodal prehabilitation program on functional status, quality of life and surgical outcome in patients undergoing neoadjuvant treatment for resectable non-small cell lung cancer - IMPROVE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033757

Enrollment

Registered

2025-03-07

Start date

2024-11-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C34

Interventions

Group 1: Preoperative: multimodal prehabilitation programme (physical exercise programme, nutritional and psychological assessment and possible intervention) Baseline and 3 follow ups: various questio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age of majority is required, no upper age limit 2. Resectable Non-Small Cell lung Cancer Stage II-IIIB 3. indication for neoadjuvant treatment (Chemo alone, Chemo-IO, with or without radiation therapy) 4. Willingness and ability to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow-up

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
completion of neoadjuvant prehabilitation therapy, training adherence	—

Secondary

Measure	Time frame
functional status (measured by spirometry, 6-minute walk test, CPET and the postoperative morbidity and quality of life measured by the EORTC QLQ-C30 as well as the EORTC QLQ-LC13 questionnaire preoperatively, postoperatively as well as 3, 6 and 12 months after resection), impact on anxiety and stress (HADS and PS-10 questionnaires), nutritional status, treatment continuation rate if indicated, length of hospital stay, readmission rate	—

Measure

Time frame

functional status (measured by spirometry, 6-minute walk test, CPET and the postoperative morbidity and quality of life measured by the EORTC QLQ-C30 as well as the EORTC QLQ-LC13 questionnaire preoperatively, postoperatively as well as 3, 6 and 12 months after resection), impact on anxiety and stress (HADS and PS-10 questionnaires), nutritional status, treatment continuation rate if indicated, length of hospital stay, readmission rate

—

Countries

Germany

Contacts

Public ContactSeverin Schmid

Universitätsklinikum Freiburg, Klinik für Thoraxchirurgie

Severin.Schmid@uniklinik-freiburg.de0761-270 24010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026