Impact of inspiratory time in the respiratory cycle on respiratory mechanics and on homogeneity of lung ventilation in mechanically ventilated pediatric oncology patients with acute respiratory distress syndrome - a pilote study

Impact of inspiratory time in the respiratory cycle on respiratory mechanics and on homogeneity of lung ventilation in mechanically ventilated pediatric oncology patients with acute respiratory distress syndrome - a pilote study - Inspiratory time_pARDS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033744

Enrollment

Registered

2024-10-15

Start date

2026-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80.0

Interventions

Group 1: 5 mechanically ventialted patients between 4 weeks and 16 years old suffering from an pediatric acute respiratory distress syndrome and an oncologic diagnosis and/or after hematopoeic stem c

Eligibility

Sex/Gender

All

Age

4 Weeks to 16 Years

Inclusion criteria

Inclusion criteria: 1. Patient with an oncologic diagnosis and/or after hematopoeic stem cell transplantation 2. Mechanical ventilation due to a pARDS (as defined in the PALICC-2 recommendations) 3. Declaration of consent of the parent/legal guardian

Exclusion criteria

Exclusion criteria: 1. Inspiratory peak pressure > 45 cmH2O 2. Endotracheal tube leak > 30%

Design outcomes

Primary

Measure	Time frame
Influence of inspiratory time on airway flow and pressure	—

Secondary

Measure	Time frame
• Influence of inspiratory time on lung compliance and airway resistance • finding of the time constants of mechanical ventilation • Influence of inspiratory time on transpulmonary pressure • EInfluence of inspiratory time on the required inspiratory peak pressure (with constant tidal volumes) • Influence of inspiratory time on the homogeneity of lung ventilation determined by electrical impedance tomography	—

Measure

Time frame

• Influence of inspiratory time on lung compliance and airway resistance • finding of the time constants of mechanical ventilation • Influence of inspiratory time on transpulmonary pressure • EInfluence of inspiratory time on the required inspiratory peak pressure (with constant tidal volumes) • Influence of inspiratory time on the homogeneity of lung ventilation determined by electrical impedance tomography

—

Countries

Germany

Contacts

Public ContactDavid Kranzhöfer

Zentrum für Kinder- und Jugendmedizin Freiburg, Klinik für Allgemeine Kinder- und Jugendmedizin, Sektion Neonatologie und Pädiatrische Intensivmedizin

david.kranzhoefer@uniklinik-freiburg.de+49 761 270 43000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026