The scientific question of the described research programme deals with the improvement of the early diagnosis of neurodegenerative diseases, especially dementia, through the further development and use of multimodal PET/MRI imaging techniques. The main aim of the project is to increase diagnostic accuracy and efficiency in order to enable more valid and reliable identification of patients with incipient memory impairment, particularly in relation to Alzheimers disease.
Conditions
Interventions
Group 1: Study group:
The scientific question of the described research program deals with the improvement of early diagnosis of neurodegenerative diseases, especially dementia, by the further develop
Sponsors
Klinik für Nuklearmedizin, Universitätsklinikum Ulm
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age: between 50-80 years Absence of neurological or psychiatric disorders, especially epilepsy, migraine, chronic tension headaches Absence of severe or chronic physical illness Absence of use of psychotropic substances Absence of pregnancy High-grade stenosis of the neck vessels (>70 %)
Exclusion criteria
Exclusion criteria: MRI exclusion criteria: - Hydrocephalus shunt - Metal implants in the head and/or body - Condition after severe craniocerebral trauma or after surgery for brain tumours brain tumours - Pacemaker - Absence of a declaration of consent Exclusion criteria for 18(F)-FDG PET examination: - The blood glucose level is determined before the FDG injection. In case of hyperglycaemia, FDG uptake may be reduced. If the glucose level is above 150-200 mg/dl, the examination cannot be performed or or at a later time after the glucose level has been checked again. - Presence of pregnancy - Because the FDG-PET examination is performed in the magnetic field of the PET /MRI device, all MRI-related exclusion criteria also apply (see exclusion criteria also apply (see above).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between F-18 FDG-PET activity and ASL perfusion | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences between the sexes and the age decades | — |
Countries
Germany
Contacts
Public ContactJoachim Strobel
Klinik für Nuklearmedizin, Universitätsklinikum Ulm
Outcome results
None listed