Effects of acute altitude exposure on non-invasively measured pulmonary shunt volume in healthy individuals compared with patients with chronic obstructive pulmonary disease (COPD)

Effects of acute altitude exposure on non-invasively measured pulmonary shunt volume in healthy individuals compared with patients with chronic obstructive pulmonary disease (COPD) - ALTISHUNT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033737

Enrollment

Registered

2024-07-02

Start date

2023-07-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J44.9

Interventions

Group 1: Healthy volunteers with pulmonary shunt measurement via ALPE and capnovolumetry under lowland and subsequently altitude (2650 m MSL) conditions during two measurement days before and after ex

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy subjects: minor illnesses not relevant to the study (e.g. stable hypothyroidism, orthopaedic complaints), near-normal lung function Subjects with COPD: diseases not relevant to the study (e.g. stable hypothyroidism, orthopaedic complaints)

Exclusion criteria

Exclusion criteria: Healthy subjects: Fear of travelling on cable cars, clinically manifest heart disease (e.g. coronary heart disease) or other serious illnesses with the risk of acute deterioration Subjects with COPD: Fear of travelling on cable cars, FEV1 <50 %, Need for or already established long-term oxygen therapy, multiple exacerbations within a year, clinically manifest heart disease (e.g. coronary heart disease)

Design outcomes

Primary

Measure	Time frame
The aim of the study is to use the ALPE and capnovolumetry measurement methods for the first time to asess pulmonary shunt volume in a comparison of lowland and altitude conditions	—

Secondary

Measure	Time frame
Validity of the results in comparison of the measurement methods	—

Countries

Germany

Contacts

Public ContactThomas Melzer

LMU-Klinikum

Thomas.Melzer@med.uni-muenchen.de004915257907292

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026