Characterization of mechanical and inflammatory bone marrow edema of the sacroiliac joints using quantitative MR imaging and perfusion CT

Characterization of mechanical and inflammatory bone marrow edema of the sacroiliac joints using quantitative MR imaging and perfusion CT - Chast-MRI Study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033725

Enrollment

128

Registered

2024-03-05

Start date

2024-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M45.0

Interventions

Group 1: The study is divided into two phases: 1st phase: First, patients with purely mechanical bone marrow edema should be examined (n=20). Women who have given birth are particularly suitable for t

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Phase 1: • Postpartum women within 10 days of natural birth • Age > 18 years • Written declaration of consent Healthy control: • Age > 18 years • Written declaration of consent • Female gender • Existing health insurance so that in the event of incidental findings, these can be clarified Phase 2: • Known sacroiliitis associated with axial spondyloarthritis OR mechanical disease of the SIJ • Age > 18 years • Written declaration of consent

Exclusion criteria

Exclusion criteria: Phase 1: • Known or suspected rheumatological diseases • Deep-seated back pain • Recent delivery • Pacemakers or other metal implants with limited MR compatibility • Severe claustrophobia • Pregnancy • Persons incapable of consent and minors • Sensorineural hearing loss of 30 dB or more or tinnitus Phase 2: • Pacemakers or other metal implants with limited MR compatibility • Severe claustrophobia • Known intolerance to iodine-based contrast media • Renal insufficiency (GFR < 30 ml/min) • Manifest hyperthyroidism • Pregnancy • Persons incapable of consent and minors

Design outcomes

Primary

Measure	Time frame
Mean signal intensities measured in % signal increase on diffusion-weighted sequences as well as T1 and T2 mapping sequences (three primary endpoints) differ significantly between inflammatory and mechanical bone marrow edema.	—

Secondary

Measure	Time frame
• MR spectroscopic metabolite spectra differ between bone marrow edema and healthy bone tissue and between inflammatory and mechanical bone marrow edema. • The MR tomographic perfusion pattern of mechanical and inflammatory bone marrow changes differs significantly. • Using contrast-enhanced CT, bone marrow edema can be visualized on CT just as well as on MRI. • Quantitative parameters of CT perfusion correlate with those of MRI perfusion. • Texture analysis parameters (radiomics) can differentiate between inflammatory and mechanical bone marrow edema.	—

Measure

Time frame

• MR spectroscopic metabolite spectra differ between bone marrow edema and healthy bone tissue and between inflammatory and mechanical bone marrow edema. • The MR tomographic perfusion pattern of mechanical and inflammatory bone marrow changes differs significantly. • Using contrast-enhanced CT, bone marrow edema can be visualized on CT just as well as on MRI. • Quantitative parameters of CT perfusion correlate with those of MRI perfusion. • Texture analysis parameters (radiomics) can differentiate between inflammatory and mechanical bone marrow edema.

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Countries

Germany

Contacts

Public ContactDominik Deppe

Charité - Universitätsmedizin Berlin

dominik.deppe@charite.de+4930450627376

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026