M79.7
Conditions
Interventions
Group 1: Patients with fibromyalgia syndrome (OLP-FMS)
Pain threshold determination and experimental pain paradigm with heat pain stimuli
video-based OLP instruction with subsequent OLP intervention under telemedical support (Medication Event Monitoring System, MEMS and Ecological Momentary Assessment, EMA)
after 1-week intervention repeated pain threshold determination and experimental pain paradigm with heat pain stimuli, associative learning paradigm with nociceptive heat stimuli and non-nociceptive a
video-based OLP instruction with subsequent control condition under telemedical support (Ecological Momentary Assessment, EMA)
after 1-week control treatment, repeated pain threshold determination and experimental pain paradigm with heat pain stimuli, associative learning paradigm with nociceptive heat stimuli and non-nocicep
after 1-week control treat
Sponsors
Ruhr-Universität Bochum
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: FMS: confirmed diagnosis of fibromyalgia syndrome; All participants: BMI 18-30kg/m2
Exclusion criteria
Exclusion criteria: All participants: inflammatory, neuropathic or tumor pain; insufficient knowledge of German; noticeable cognitive impairments; limited legal capacity or custody by official order; use of opioids or sedatives; medication or drug dependence or abuse; illnesses that prevent lying quietly in the examination device for approx. 90 minutes (e.g. excessive pain, claustrophobia); metal parts or electrically working health aids in the body; large tattoos with metal particles Healthy participants additionally: any acute or chronic physical illnesses; acute and chronic psychiatric diagnoses according to DSM-IV Patients: acute or chronic physical illnesses other than FMS; severe psychiatric diagnoses according to DSM-IV (e.g. schizophrenia, bipolar disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of intensity of somatic pain stimuli before and after OLP intervention; assessment of aversive somatic and acoustic stimuli and visual predictive cues before and after classical fear conditioning (intensity, valence and fear); neural correlates during anticipation and experience of experimental pain stimuli | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily assessment of well-being, mood and treatment expectations using EMA during the intervention week; collection of salivary cortisol and state anxiety as markers of acute stress and arousal daily during the intervention week and at several time points during the experimental days | — |
Countries
Germany
Contacts
Public ContactMartin Diers
Ruhr-Universität Bochum
Outcome results
None listed