Young healthy male and female participants
Conditions
Interventions
Group 1: Healthy control group according to American Society of Anesthesiologists Physical Status classification (ASA PS1) between 18 and 45 years of age
No pharmacological intervention
Pain threshold
1 week later fMRI measurement and presentation of acoustic signals to reactivate the memory trace (duration approx. 45 minutes)
Group 2: Healthy intervention group 1 according to American Society of A
1 week later fMRI measurement and presentation of acoustic signals to reactivate the memory trace in the awake state (duration approx. 45 minutes)
Group 3: Healthy intervention group 2 according to Am
1 week later fMRI measurement and presentation of acoustic signals to reactivate the memory trace in the awak
Sponsors
Abteilung für Medizinische Psychologie und Medizinische Soziologie
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Physical status classification ASA PS1 according to the American Society of Anesthesiologists; BMI 18-30 kg/m2.
Exclusion criteria
Exclusion criteria: MRI-relevant factors (e.g. claustrophobia, metallic implants, etc.); any physical or mental illness; regular use of medication; indications of substance abuse including nicotine and alcohol; indications of a difficult airway (according to the airway checklist), allergies to propofol and remifentanil as well as to soy, peanuts and egg; suspected anesthesia-associated diseases (e.g. malignant hyperthermia) or assessment by the anesthesiologist for increased anesthesiological risk; changes in the anorectal area; pregnancy or breastfeeding; oral contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neural activation assessed via functional magnetic resonance imaging (fMRI) in response to acoustic conditioned cues and visceral pain stimuli; VAS ratings of stimulus intensity, valence and fear of pain and pain-predictive acoustic signals | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional and structural brain connectivity (diffusion tensor imaging, DTI; resting state functional magnetic resonance imaging, rsfMRI); questionnaires; ratings regarding memories of intensity, valence, contingency and fear; immunological analysis parameters from blood samples | — |
Countries
Germany
Contacts
Public ContactSigrid Elsenbruch
Abteilung für Medizinische Psychologie und Medizinische Soziologie
Outcome results
None listed